Rahman et al. reply

Taufiq Rahman, Alexander Skupin, Martin Falcke and Colin W. Taylor ()
Additional contact information
Taufiq Rahman: Department of Pharmacology
Alexander Skupin: Luxembourg Centre for Systems Biomedicine, 162a Avenue de la Faiencerie, University of Luxembourg
Martin Falcke: § Mathematical Cell Physiology, Max Delbruck Center for Molecular Medicine, Robert-Rössle-Str, 10, 13092 Berlin, Germany
Colin W. Taylor: Department of Pharmacology

Nature, 2011, vol. 478, issue 7368, E2-E3

Abstract: Abstract Replying to H. Vais, J. K. Foskett & D.-O. D. Mak Nature 478, doi:10.1038/nature10493 (2011) We observe that under conditions designed to mimic those of an unstimulated cell, InsP3 causes InsP3R to assemble rapidly and reversibly into small clusters of about 4–5 channels, and that gating of lone and clustered InsP3R by InsP3 and Ca2+ is different. We speculate that dynamic assembly of InsP3R clusters by InsP3 may contribute to the genesis of elementary Ca2+ release events by both assembling clusters and re-tuning the behaviour of InsP3R within them1,2,3. Vais et al.4 report that they have been unable to replicate some of our findings.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature10494 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:478:y:2011:i:7368:d:10.1038_nature10494

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10494

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().