Corridors of migrating neurons in the human brain and their decline during infancy

Nader Sanai, Thuhien Nguyen, Rebecca A. Ihrie, Zaman Mirzadeh, Hui-Hsin Tsai, Michael Wong, Nalin Gupta, Mitchel S. Berger, Eric Huang, Jose-Manuel Garcia-Verdugo, David H. Rowitch () and Arturo Alvarez-Buylla ()
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Nader Sanai: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
Thuhien Nguyen: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
Rebecca A. Ihrie: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
Zaman Mirzadeh: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
Hui-Hsin Tsai: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
Michael Wong: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
Nalin Gupta: University of California San Francisco
Mitchel S. Berger: University of California San Francisco
Eric Huang: University of California San Francisco
Jose-Manuel Garcia-Verdugo: Laboratorio de Morfología Celular, Unidad Mixta CIPF-UVEG
David H. Rowitch: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco
Arturo Alvarez-Buylla: Eli and Edythe Broad Institute of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco

Nature, 2011, vol. 478, issue 7369, 382-386

Abstract: Neurogenesis in the infant brain In adult mammals, the subventricular zone is known to be one of the few sources for new neurons in the brain, but the contributions of these progenitors to distinct regions of the postnatal human brain are poorly understood. A study of human brain specimens from neurosurgical resections and autopsies ranging in age from birth to 84 years reveals extensive migration and proliferation of neuronal precursors along the rostral stream in human infants. After about 18 months of age, this subsides and is almost extinct in adulthood. During this limited time of neurogenesis, a novel stream of cells destined for the prefrontal cortex was also observed. These findings reconcile some conflicting reports in the literature and reveal new trajectories for tangentially migrating immature neurons during human brain development.

Date: 2011
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DOI: 10.1038/nature10487

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