A vascular niche and a VEGF–Nrp1 loop regulate the initiation and stemness of skin tumours

Benjamin Beck, Gregory Driessens, Steven Goossens, Khalil Kass Youssef, Anna Kuchnio, Amélie Caauwe, Panagiota A. Sotiropoulou, Sonja Loges, Gaelle Lapouge, Aurélie Candi, Guilhem Mascre, Benjamin Drogat, Sophie Dekoninck, Jody J. Haigh, Peter Carmeliet and Cédric Blanpain ()
Additional contact information
Benjamin Beck: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Gregory Driessens: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Steven Goossens: Vascular Cell Biology Unit
Khalil Kass Youssef: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Anna Kuchnio: UGent Department for Molecular Biomedical Research
Amélie Caauwe: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Panagiota A. Sotiropoulou: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Sonja Loges: Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB
Gaelle Lapouge: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Aurélie Candi: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Guilhem Mascre: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Benjamin Drogat: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Sophie Dekoninck: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik
Jody J. Haigh: Vascular Cell Biology Unit
Peter Carmeliet: Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB
Cédric Blanpain: IRIBHM, Université Libre de Bruxelles, 808 route de Lennik

Nature, 2011, vol. 478, issue 7369, 399-403

Abstract: Targeting a cancer stem-cell niche Experiments in a mouse model of skin papillomas show that the tumour vasculature not only supplies blood, but also serves as a vascular niche environment that supports cancer stem cells. Vascular endothelial growth factor (VEGF) expression by tumour cells is important for angiogenesis, but also acts in an autocrine manner through its receptor to promote self-renewing divisions of cancer stem cells. Deletion of Nrp1 blocked the ability of VEGF to promote tumorigenesis, and may be a viable therapeutic target for skin cancers.

Date: 2011
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DOI: 10.1038/nature10525

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