Few inputs can reprogram biological networks

Franz-Josef Müller () and Andreas Schuppert
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Franz-Josef Müller: Zentrum für Integrative Psychiatrie, Niemannsweg 147
Andreas Schuppert: Graduiertenschule Aachen Institute for Advanced Study in Computational Engineering Science (AICES), RWTH Aachen University, Schinkelstrasse 2

Nature, 2011, vol. 478, issue 7369, E4-E4

Abstract: Abstract Arising from Y. Liu, J. Slotine & A. Barabási Nature 473, 167–173 (2011)10.1038/nature10011 ; Liu et al. reply Liu, Slotine and Barabasi1 identify subsets U of nodes in complex networks, which are required to exert full control of these networks. Control in this context means that for each possible state S of the network there exist inputs for all nodes in U, which are sufficient to force the network to state S1. Application of the methodology to gene regulatory networks suggests that roughly 80% of all nodes must be controlled to drive such a network. This seems to contradict recent empirical findings2,3,4,5,6 in the cellular reprogramming field.

Date: 2011
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DOI: 10.1038/nature10543

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