STING is a direct innate immune sensor of cyclic di-GMP

Dara L. Burdette, Kathryn M. Monroe, Katia Sotelo-Troha, Jeff S. Iwig, Barbara Eckert, Mamoru Hyodo, Yoshihiro Hayakawa and Russell E. Vance ()
Additional contact information
Dara L. Burdette: University of California
Kathryn M. Monroe: University of California
Katia Sotelo-Troha: University of California
Jeff S. Iwig: University of California
Barbara Eckert: University of California
Mamoru Hyodo: Faculty of Pharmaceutical Science, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan
Yoshihiro Hayakawa: Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa, Toyota 470-0392, Japan
Russell E. Vance: University of California

Nature, 2011, vol. 478, issue 7370, 515-518

Abstract: Bacterial metabolites recognized by STING Cyclic dinucleotides, used as signalling molecules in bacteria but not in mammalian cells, are recognized by the mammalian innate immune system, triggering the production of type I interferon. Here the mammalian protein STING (stimulator of IFN genes) is identified as the direct molecular sensor for cyclic diguanylate monophosphate and other cyclic dinucleotides. Previously, STING was thought to act solely as a downstream signalling adaptor. Cyclic dinucleotides are potent immunostimulants, and may prove useful therapeutically.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (7)

Downloads: (external link)
https://www.nature.com/articles/nature10429 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:478:y:2011:i:7370:d:10.1038_nature10429

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10429

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().