Temporal dynamics and genetic control of transcription in the human prefrontal cortex

Carlo Colantuoni, Barbara K. Lipska, Tianzhang Ye, Thomas M. Hyde, Ran Tao, Jeffrey T. Leek, Elizabeth A. Colantuoni, Abdel G. Elkahloun, Mary M. Herman, Daniel R. Weinberger and Joel E. Kleinman ()
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Carlo Colantuoni: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Barbara K. Lipska: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Tianzhang Ye: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Thomas M. Hyde: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Ran Tao: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Jeffrey T. Leek: Johns Hopkins Bloomberg School of Public Health
Elizabeth A. Colantuoni: Johns Hopkins Bloomberg School of Public Health
Abdel G. Elkahloun: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health
Mary M. Herman: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Daniel R. Weinberger: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA
Joel E. Kleinman: Section on Neuropathology, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, IRP, NIMH, NIH, Bethesda, Maryland 20892, USA

Nature, 2011, vol. 478, issue 7370, 519-523

Abstract: Gene expression in the human brain Gene expression controls and dictates everything from development and plasticity to ongoing neurogenesis in the brain, yet the temporal dynamics of transcription throughout the brain's lifetime have been mostly unknown. Here, two groups present a large gene-expression database from a variety of human brain samples ranging from before birth to over 80 years in age. Colantuoni et al. focus on the prefrontal cortex. Although they note significant expression pattern dynamics throughout development, they identify a consistent molecular architecture of transcription across subjects from different races despite the large number of genetic polymorphisms among them. Kang et al. produce a more comprehensive time course, exploring expression in 16 different brain areas, determining that the largest spatiotemporal variability occurs before birth, with transcriptomes in brain regions converging as we age.

Date: 2011
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DOI: 10.1038/nature10524

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