Derivation of haploid embryonic stem cells from mouse embryos

Martin Leeb and Anton Wutz ()
Additional contact information
Martin Leeb: Wellcome Trust Centre for Stem Cell Research, University of Cambridge
Anton Wutz: Wellcome Trust Centre for Stem Cell Research, University of Cambridge

Nature, 2011, vol. 479, issue 7371, 131-134

Abstract: Mouse stem cells made haploid The diploid state that predominates in the genomes of complex organisms limits the variety of genetic approaches that can be used in biomedical model species such as mice. It has been previously suggested that because of the specifics of mammalian genetics, such as genomic imprinting and X inactivation, it is not possible to derive haploid stem cells from mice. But a study by Martin Leeb and Anton Wutz reports the successful production of mouse haploid embryonic stem cells. The cell lines can be established in culture and will open new possibilities for genetic screening in mammals.

Date: 2011
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature10448 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:479:y:2011:i:7371:d:10.1038_nature10448

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10448

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().