Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors

Daniel Vasiliauskas, Esteban O. Mazzoni, Simon G. Sprecher, Konstantin Brodetskiy, Robert J. Johnston, Preetmoninder Lidder, Nina Vogt, Arzu Celik and Claude Desplan ()
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Daniel Vasiliauskas: Center for Developmental Genetics, New York University
Esteban O. Mazzoni: Center for Developmental Genetics, New York University
Simon G. Sprecher: Center for Developmental Genetics, New York University
Konstantin Brodetskiy: Center for Developmental Genetics, New York University
Robert J. Johnston: Center for Developmental Genetics, New York University
Preetmoninder Lidder: Center for Developmental Genetics, New York University
Nina Vogt: Center for Developmental Genetics, New York University
Arzu Celik: Center for Developmental Genetics, New York University
Claude Desplan: Center for Developmental Genetics, New York University

Nature, 2011, vol. 479, issue 7371, 108-112

Abstract: Cross-repression of sense receptors Some of the senses, such as colour vision and olfaction, rely on single sensory neurons to produce a specific chemical- or light-sensing G-protein coupled receptor. Various mechanisms have been proposed to explain exclusive gene expression in olfactory receptors, but the molecular pathways remain unknown. Claude Desplan and colleagues report that mature Drosophila R8 photoreceptors of the subtype that normally expresses green-sensing rhodopsin 6 protein can express the 'wrong' blue-sensing rhodopsin 5 when fruitflies are either kept in the dark or mutated in rhodopsin 6. Light thus achieves a negative feedback on the rh5 gene by repressing its transcription in rh6-expressing neurons, a system resembling the control of olfactory receptor genes in vertebrate olfactory neurons.

Date: 2011
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DOI: 10.1038/nature10451

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