RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II

Mikel Zaratiegui, Stephane E. Castel, Danielle V. Irvine, Anna Kloc, Jie Ren, Fei Li, Elisa de Castro, Laura Marín, An-Yun Chang, Derek Goto, W. Zacheus Cande, Francisco Antequera, Benoit Arcangioli and Robert A. Martienssen ()
Additional contact information
Mikel Zaratiegui: Cold Spring Harbor Laboratory, Cold Spring Harbor
Stephane E. Castel: Cold Spring Harbor Laboratory, Cold Spring Harbor
Danielle V. Irvine: Cold Spring Harbor Laboratory, Cold Spring Harbor
Anna Kloc: Cold Spring Harbor Laboratory, Cold Spring Harbor
Jie Ren: Cold Spring Harbor Laboratory, Cold Spring Harbor
Fei Li: Molecular and Cellular Biology, University of California Berkeley
Elisa de Castro: Instituto de Biología Funcional y Genómica. CSIC/Universidad de Salamanca
Laura Marín: Instituto de Biología Funcional y Genómica. CSIC/Universidad de Salamanca
An-Yun Chang: Cold Spring Harbor Laboratory, Cold Spring Harbor
Derek Goto: Cold Spring Harbor Laboratory, Cold Spring Harbor
W. Zacheus Cande: Molecular and Cellular Biology, University of California Berkeley
Francisco Antequera: Instituto de Biología Funcional y Genómica. CSIC/Universidad de Salamanca
Benoit Arcangioli: Cold Spring Harbor Laboratory, Cold Spring Harbor
Robert A. Martienssen: Cold Spring Harbor Laboratory, Cold Spring Harbor

Nature, 2011, vol. 479, issue 7371, 135-138

Abstract: RNAi keeps replication on track Transcription of heterochromatin during DNA replication regularly results in collision between DNA and RNA polymerases, and fork stalling can follow. Replication origins and silent heterochromatin, formed by RNA interference (RNAi), exhibit an alternating pattern near chromosome centromeres. Zaratiegui et al. show that RNAi displaces the RNA polymerase so that replication can be completed by the DNA polymerase. Histone-modifying enzymes travel with the replication fork, and in the absence of RNAi, stalled forks are repaired by recombination, but histone modifications are not made.

Date: 2011
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DOI: 10.1038/nature10501

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