Non-canonical inflammasome activation targets caspase-11

Nobuhiko Kayagaki (), Søren Warming, Mohamed Lamkanfi, Lieselotte Vande Walle, Salina Louie, Jennifer Dong, Kim Newton, Yan Qu, Jinfeng Liu, Sherry Heldens, Juan Zhang, Wyne P. Lee, Merone Roose-Girma and Vishva M. Dixit ()
Additional contact information
Nobuhiko Kayagaki: Genentech Inc.
Søren Warming: Genentech Inc.
Mohamed Lamkanfi: VIB
Lieselotte Vande Walle: VIB
Salina Louie: Genentech Inc.
Jennifer Dong: Genentech Inc.
Kim Newton: Genentech Inc.
Yan Qu: Genentech Inc.
Jinfeng Liu: Genentech Inc.
Sherry Heldens: Genentech Inc.
Juan Zhang: Genentech Inc.
Wyne P. Lee: Genentech Inc.
Merone Roose-Girma: Genentech Inc.
Vishva M. Dixit: Genentech Inc.

Nature, 2011, vol. 479, issue 7371, 117-121

Abstract: Key role for caspase-11 in innate immunity It has long been presumed that caspase-11 is pro-inflammatory because of its homology to caspase-1, but its actual role has been enigmatic. Vishva Dixit and co-workers now report a crucial role for caspase-11 in inflammasome activation by various pathogenic Gram-negative bacteria, and show that lipopolysaccharide toxicity depends on caspase-11 — not on caspase-1 as previously thought. This work highlights a pro-inflammatory role for caspase-11 in the innate immune response to bacterial infections.

Date: 2011
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DOI: 10.1038/nature10558

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