ATM controls meiotic double-strand-break formation

Julian Lange, Jing Pan, Francesca Cole, Michael P. Thelen, Maria Jasin () and Scott Keeney ()
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Julian Lange: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center
Jing Pan: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center
Francesca Cole: Developmental Biology Program, Memorial Sloan-Kettering Cancer Center
Michael P. Thelen: Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory
Maria Jasin: Developmental Biology Program, Memorial Sloan-Kettering Cancer Center
Scott Keeney: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center

Nature, 2011, vol. 479, issue 7372, 237-240

Abstract: Keeping a cap on DNA strand breakage During meiosis, a limited number of double-strand breaks are made in the DNA by Spo11 protein to facilitate correct chromosome segregation. The level of Spo11 is in considerable excess to the number of strand breaks that are made, suggesting that some mechanism is at work to limit its activity. Scott Keeney and colleagues show that ATM kinase, which has a central role in repair of spontaneous double-strand breaks, also functions in a feedback loop to restrain meiotic strand breakage.

Date: 2011
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DOI: 10.1038/nature10508

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