Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

Jie Liu, Ludovic Renault, Xavier Veaute, Francis Fabre, Henning Stahlberg and Wolf-Dietrich Heyer ()
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Jie Liu: University of California, Davis
Ludovic Renault: University of California, Davis
Xavier Veaute: CEA-DSV-Institut de Radiobiologie Cellulaire et Moléculaire, UMR217 CNRS/CEA
Francis Fabre: CEA-DSV-Institut de Radiobiologie Cellulaire et Moléculaire, UMR217 CNRS/CEA
Henning Stahlberg: University of California, Davis
Wolf-Dietrich Heyer: University of California, Davis

Nature, 2011, vol. 479, issue 7372, 245-248

Abstract: Rad51 and DNA repair DNA strand exchange, a process that helps to maintain the integrity of the genome, is promoted in eukaryotes by the Rad51 protein. Eukaryotes also have homologues of Rad51 with functions that are less well defined. Wolf-Dietrich Heyer and colleagues show that in yeast, two of these proteins, Rad55 and Rad57, form a complex that promotes recombination by stabilizing the Rad51 filament against the anti-recombinogenic activity of a helicase, Srs2. These results suggest that the Rad51 filament is a reversible intermediate, the stability of which reflects competing actions of other proteins. This mechanism may have relevance for the human RAD51 paralogues that have important roles in tumour suppression and disease.

Date: 2011
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DOI: 10.1038/nature10522

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