Genome sequencing reveals insights into physiology and longevity of the naked mole rat

Eun Bae Kim, Xiaodong Fang, Alexey A. Fushan, Zhiyong Huang, Alexei V. Lobanov, Lijuan Han, Stefano M. Marino, Xiaoqing Sun, Anton A. Turanov, Pengcheng Yang, Sun Hee Yim, Xiang Zhao, Marina V. Kasaikina, Nina Stoletzki, Chunfang Peng, Paz Polak, Zhiqiang Xiong, Adam Kiezun, Yabing Zhu, Yuanxin Chen, Gregory V. Kryukov, Qiang Zhang, Leonid Peshkin, Lan Yang, Roderick T. Bronson, Rochelle Buffenstein, Bo Wang, Changlei Han, Qiye Li, Li Chen, Wei Zhao, Shamil R. Sunyaev, Thomas J. Park, Guojie Zhang (), Jun Wang () and Vadim N. Gladyshev ()
Additional contact information
Eun Bae Kim: Ewha Womans University
Xiaodong Fang: BGI-Shenzhen
Alexey A. Fushan: Ewha Womans University
Zhiyong Huang: BGI-Shenzhen
Alexei V. Lobanov: Brigham and Women’s Hospital, Harvard Medical School
Lijuan Han: BGI-Shenzhen
Stefano M. Marino: Brigham and Women’s Hospital, Harvard Medical School
Xiaoqing Sun: BGI-Shenzhen
Anton A. Turanov: Brigham and Women’s Hospital, Harvard Medical School
Pengcheng Yang: BGI-Shenzhen
Sun Hee Yim: Brigham and Women’s Hospital, Harvard Medical School
Xiang Zhao: BGI-Shenzhen
Marina V. Kasaikina: Brigham and Women’s Hospital, Harvard Medical School
Nina Stoletzki: Brigham and Women’s Hospital, Harvard Medical School
Chunfang Peng: BGI-Shenzhen
Paz Polak: Brigham and Women’s Hospital, Harvard Medical School
Zhiqiang Xiong: BGI-Shenzhen
Adam Kiezun: Brigham and Women’s Hospital, Harvard Medical School
Yabing Zhu: BGI-Shenzhen
Yuanxin Chen: BGI-Shenzhen
Gregory V. Kryukov: Brigham and Women’s Hospital, Harvard Medical School
Qiang Zhang: BGI-Shenzhen
Leonid Peshkin: Harvard Medical School
Lan Yang: BGI-Shenzhen
Roderick T. Bronson: Rodent Histopathology Laboratory, Harvard Medical School
Rochelle Buffenstein: University of Texas Health Science Center
Bo Wang: BGI-Shenzhen
Changlei Han: BGI-Shenzhen
Qiye Li: BGI-Shenzhen
Li Chen: BGI-Shenzhen
Wei Zhao: BGI-Shenzhen
Shamil R. Sunyaev: Brigham and Women’s Hospital, Harvard Medical School
Thomas J. Park: University of Illinois at Chicago
Guojie Zhang: BGI-Shenzhen
Jun Wang: BGI-Shenzhen
Vadim N. Gladyshev: Ewha Womans University

Nature, 2011, vol. 479, issue 7372, 223-227

Abstract: It's in the genes The mouse-sized naked mole rat (Heterocephalus glaber) is a very unusual mammal. It is a social animal, living in groups in burrows beneath arid African deserts. It can live for 30 or more years in atmospheres with low oxygen and high carbon dioxide, and is remarkably resistant to cancer. So the genome sequence, published in this issue, might be expected to contain some intriguing characteristics. Analysis of the genome and its transcriptome reveals unusual genomic features and molecular adaptations including strategies for improved genome stability, low mutation rate and improved protein maintenance. The data also reveal molecular adaptations consistent with poor visual function, poikilothermy, hairlessness, circadian rhythms, taste sensing and insensitivity to low oxygen.

Date: 2011
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DOI: 10.1038/nature10533

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