Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K. LeBrasseur, Bennett G. Childs, Bart van de Sluis, James L. Kirkland and Jan M. van Deursen ()
Additional contact information
Darren J. Baker: Mayo Clinic College of Medicine
Tobias Wijshake: Mayo Clinic College of Medicine
Tamar Tchkonia: Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
Nathan K. LeBrasseur: Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
Bennett G. Childs: Mayo Clinic College of Medicine
Bart van de Sluis: University Medical Center Groningen, Groningen University
James L. Kirkland: Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine
Jan M. van Deursen: Mayo Clinic College of Medicine

Nature, 2011, vol. 479, issue 7372, 232-236

Abstract: Role of cell senescence in ageing Senescent cells accumulate in tissues with age, but it is not known whether they actually cause age-related dysfunction or whether their removal is beneficial. Using a mouse model with a transgene named INK-ATTAC, which allows for the inducible elimination of cells carrying the senescence biomarker p16Ink4a, Baker et al. demonstrate that life-long removal of senescent cells delays the onset of age-related phenotypes. Furthermore, late-life clearance attenuated the progression of already established age-related disorders. This indicates that senescent cells do cause age-related phenotypes and that their removal can prevent or delay age-related tissue dysfunction.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (15)

Downloads: (external link)
https://www.nature.com/articles/nature10600 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:479:y:2011:i:7372:d:10.1038_nature10600

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10600

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().