Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B

Julian P. Vivian, Renee C. Duncan, Richard Berry, Geraldine M. O’Connor, Hugh H. Reid, Travis Beddoe, Stephanie Gras, Philippa M. Saunders, Maya A. Olshina, Jacqueline M. L. Widjaja, Christopher M. Harpur, Jie Lin, Sebastien M. Maloveste, David A. Price, Bernard A. P. Lafont, Daniel W. McVicar, Craig S. Clements, Andrew G. Brooks and Jamie Rossjohn
Additional contact information
Julian P. Vivian: School of Biomedical Sciences, Monash University
Renee C. Duncan: School of Biomedical Sciences, Monash University
Richard Berry: School of Biomedical Sciences, Monash University
Geraldine M. O’Connor: Cancer and Inflammation Program, National Cancer Institute-Frederick
Hugh H. Reid: School of Biomedical Sciences, Monash University
Travis Beddoe: School of Biomedical Sciences, Monash University
Stephanie Gras: School of Biomedical Sciences, Monash University
Philippa M. Saunders: University of Melbourne
Maya A. Olshina: School of Biomedical Sciences, Monash University
Jacqueline M. L. Widjaja: University of Melbourne
Christopher M. Harpur: University of Melbourne
Jie Lin: University of Melbourne
Sebastien M. Maloveste: Non-Human Primate Immunogenetics and Cellular Immunology Unit, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
David A. Price: Immunity and Biochemistry, Cardiff University School of Medicine, Heath Park
Bernard A. P. Lafont: Non-Human Primate Immunogenetics and Cellular Immunology Unit, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Daniel W. McVicar: Cancer and Inflammation Program, National Cancer Institute-Frederick
Craig S. Clements: School of Biomedical Sciences, Monash University
Andrew G. Brooks: University of Melbourne
Jamie Rossjohn: School of Biomedical Sciences, Monash University

Nature, 2011, vol. 479, issue 7373, 401-405

Abstract: HLA recognition by a killer receptor The interaction between the three-domain killer immunoglobulin receptor (KIR3D) and human leukocyte antigen (HLA) class I molecules is central to the regulation of natural killer cell activity, as well as being key to the control of HIV replication and some haematological malignancies. The crystal structure of a complex between a KIR3D and a self-peptide bearing HLA-B57 molecule has now been determined. The structure shows why the KIR3D family is specific for the HLA-B locus, whereas KIR2D receptors are restricted to HLA-C.

Date: 2011
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DOI: 10.1038/nature10517

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