Somatic retrotransposition alters the genetic landscape of the human brain

J. Kenneth Baillie, Mark W. Barnett, Kyle R. Upton, Daniel J. Gerhardt, Todd A. Richmond, Fioravante De Sapio, Paul M. Brennan, Patrizia Rizzu, Sarah Smith, Mark Fell, Richard T. Talbot, Stefano Gustincich, Thomas C. Freeman, John S. Mattick, David A. Hume, Peter Heutink, Piero Carninci, Jeffrey A. Jeddeloh and Geoffrey J. Faulkner ()
Additional contact information
J. Kenneth Baillie: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Mark W. Barnett: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Kyle R. Upton: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Daniel J. Gerhardt: Roche NimbleGen, Inc., 500 South Rosa Road, Madison, Wisconsin 53719, USA
Todd A. Richmond: Roche NimbleGen, Inc., 500 South Rosa Road, Madison, Wisconsin 53719, USA
Fioravante De Sapio: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Paul M. Brennan: Edinburgh Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK
Patrizia Rizzu: Section of Medical Genomics, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Sarah Smith: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Mark Fell: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Richard T. Talbot: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Stefano Gustincich: Sector of Neurobiology, International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy
Thomas C. Freeman: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
John S. Mattick: Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia
David A. Hume: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK
Peter Heutink: Section of Medical Genomics, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Piero Carninci: RIKEN Yokohama Institute, Omics Science Center, 1-7-22 Suehiro-chô, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Jeffrey A. Jeddeloh: Roche NimbleGen, Inc., 500 South Rosa Road, Madison, Wisconsin 53719, USA
Geoffrey J. Faulkner: The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK

Nature, 2011, vol. 479, issue 7374, 534-537

Abstract: Reshaping the brain's genetic circuits Mobilization of retrotransposons, genetic elements able to move around in the genome where they can become incorporated and start to amplify themselves, is normally suppressed in somatic cells. However, recent reports indicate that L1 retrotransposons can be mobilized in the human brain; this has important consequences for intercellular variation. Using a high-throughput approach, Baillie et al. identify numerous germ-line mutations and putative somatic insertions in the human hippocampus and caudate nucleus, including those of Alu elements. The implication is that retrotransposition-driven somatic mosaicism may reshape the genetic circuitry that underpins normal and abnormal neurobiological processes.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature10531 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:479:y:2011:i:7374:d:10.1038_nature10531

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10531

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().