Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

Christine Moussion and Jean-Philippe Girard ()
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Christine Moussion: CNRS, Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne
Jean-Philippe Girard: CNRS, Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne

Nature, 2011, vol. 479, issue 7374, 542-546

Abstract: Dendritic cells in immune surveillance Christine Moussion and Jean-Philippe Girard report that dendritic cells in the immune system have an unexpected immune surveillance role in lymphocyte recirculation during homeostasis. Lymphotoxin ligands derived from dendritic cells promote the growth of high endothelial venules — blood vessels specialized in lymphocyte recruitment — which control the entry of naive lymphocytes from the blood into lymph nodes.

Date: 2011
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DOI: 10.1038/nature10540

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