Control of Drosophila endocycles by E2F and CRL4CDT2

Norman Zielke, Kerry J. Kim, Vuong Tran, Shusaku T. Shibutani, Maria-Jose Bravo, Sabarish Nagarajan, Monique van Straaten, Brigitte Woods, George von Dassow, Carmen Rottig, Christian F. Lehner, Savraj S. Grewal, Robert J. Duronio and Bruce A. Edgar ()
Additional contact information
Norman Zielke: German Cancer Research Center (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Kerry J. Kim: Center for Cell Dynamics, Friday Harbor Labs, University of Washington, 620 University Road
Vuong Tran: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Shusaku T. Shibutani: University of North Carolina
Maria-Jose Bravo: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Sabarish Nagarajan: Clark H. Smith Brain Tumor Center, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada
Monique van Straaten: German Cancer Research Center (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Brigitte Woods: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
George von Dassow: Center for Cell Dynamics, Friday Harbor Labs, University of Washington, 620 University Road
Carmen Rottig: Institute of Molecular and Life Sciences (IMLS), Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
Christian F. Lehner: Institute of Molecular and Life Sciences (IMLS), Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
Savraj S. Grewal: Clark H. Smith Brain Tumor Center, Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive, Calgary, Alberta T2N 4N1, Canada
Robert J. Duronio: University of North Carolina
Bruce A. Edgar: German Cancer Research Center (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany

Nature, 2011, vol. 480, issue 7375, 123-127

Abstract: Pyruvate kinase in tumour cells Pyruvate kinase M2 (PKM2) is a key enzyme in glycolysis that is highly expressed in cancer. Here, Zhimin Lu and colleagues show that PKM2 can translocate to the nucleus in response to epidermal growth factor, where it contributes to β-catenin-dependent gene activation. This non-metabolic function of PKM2 seems to be important for tumour cell proliferation.

Date: 2011
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DOI: 10.1038/nature10579

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