Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Khoa D. Nguyen, Yifu Qiu, Xiaojin Cui, Y. P. Sharon Goh, Julia Mwangi, Tovo David, Lata Mukundan, Frank Brombacher, Richard M. Locksley and Ajay Chawla ()
Additional contact information
Khoa D. Nguyen: Immunology Program, Stanford University
Yifu Qiu: Cardiovascular Research Institute, University of California
Xiaojin Cui: Cardiovascular Research Institute, University of California
Y. P. Sharon Goh: Immunology Program, Stanford University
Julia Mwangi: Cardiovascular Research Institute, University of California
Tovo David: Cardiovascular Research Institute, University of California
Lata Mukundan: Cardiovascular Research Institute, University of California
Frank Brombacher: Institute of Infectious Disease and Molecular Medicine, University of Cape Town
Richard M. Locksley: Howard Hughes Medical Institute, University of California
Ajay Chawla: Cardiovascular Research Institute, University of California

Nature, 2011, vol. 480, issue 7375, 104-108

Abstract: Exposure to cold drives IL-4-mediated alternative macrophage activation and catecholamine secretion in brown and white adipose tissues to stimulate thermogenesis.

Date: 2011
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DOI: 10.1038/nature10653

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