Spontaneous epigenetic variation in the Arabidopsis thaliana methylome

Claude Becker, Jörg Hagmann, Jonas Müller, Daniel Koenig, Oliver Stegle, Karsten Borgwardt and Detlef Weigel ()
Additional contact information
Claude Becker: Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
Jörg Hagmann: Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
Jonas Müller: Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
Daniel Koenig: Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany
Oliver Stegle: Machine Learning and Computational Biology Research Group, Max Planck Institute for Developmental Biology and Max Planck Institute for Intelligent Systems, 72076 Tübingen, Germany
Karsten Borgwardt: Machine Learning and Computational Biology Research Group, Max Planck Institute for Developmental Biology and Max Planck Institute for Intelligent Systems, 72076 Tübingen, Germany
Detlef Weigel: Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany

Nature, 2011, vol. 480, issue 7376, 245-249

Abstract: Epigenetic variation in evolution The extent to which inherited epigenetic differences contribute to phenotypic variation and hence to evolution is a topic of intense research. This comparison of genome-wide DNA methylation among 10 Arabidopsis thaliana lines, derived from a common ancestor and maintained for 30 generations, shows that the methylation status of individual bases is dynamic. Hundreds of thousands of differentially methylated cytosines are generated, but wholesale changes of blocks of methylated cytosines — which have been linked to changes in gene expression and phenotypic differences — are rare and not random. So when differences arise, they often occur in more than one line.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/nature10555 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:480:y:2011:i:7376:d:10.1038_nature10555

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10555

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().