Aspartate 112 is the selectivity filter of the human voltage-gated proton channel

Boris Musset, Susan M. E. Smith, Sindhu Rajan, Deri Morgan, Vladimir V. Cherny and Thomas E. DeCoursey ()
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Boris Musset: Rush University Medical Center
Susan M. E. Smith: Emory School of Medicine
Sindhu Rajan: University of Chicago
Deri Morgan: Rush University Medical Center
Vladimir V. Cherny: Rush University Medical Center
Thomas E. DeCoursey: Rush University Medical Center

Nature, 2011, vol. 480, issue 7376, 273-277

Abstract: Aspartate key to proton selectivity Voltage-gated proton channels are considered completely selective for protons — no evidence exists for the permeation of ions other than H+. A study of the underlying mechanism of the high selectivity of the human voltage-gated proton channel reveals an Asp112 residue as the selectivity filter. When this residue was changed to a neutral amino acid, the mutant channel lost proton selectivity and either became anion-selective or did not conduct any ions.

Date: 2011
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DOI: 10.1038/nature10557

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