Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

Michael Reuter, Philipp Berninger, Shinichiro Chuma, Hardik Shah, Mihoko Hosokawa, Charlotta Funaya, Claude Antony, Ravi Sachidanandam and Ramesh S. Pillai ()
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Michael Reuter: European Molecular Biology Laboratory, 6 Rue Jules Horowitz, BP 181, 38042 Grenoble, France
Philipp Berninger: European Molecular Biology Laboratory, 6 Rue Jules Horowitz, BP 181, 38042 Grenoble, France
Shinichiro Chuma: Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
Hardik Shah: Mount Sinai School of Medicine
Mihoko Hosokawa: Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
Charlotta Funaya: European Molecular Biology Laboratory, EMBL Meyerhof Str. 1, 69117 Heidelberg, Germany
Claude Antony: European Molecular Biology Laboratory, EMBL Meyerhof Str. 1, 69117 Heidelberg, Germany
Ravi Sachidanandam: Mount Sinai School of Medicine
Ramesh S. Pillai: European Molecular Biology Laboratory, 6 Rue Jules Horowitz, BP 181, 38042 Grenoble, France

Nature, 2011, vol. 480, issue 7376, 264-267

Abstract: Piwi protein Miwi is shown to be a small RNA-guided RNase in mice; disrupting the catalytic activity of Miwi results in increased accumulation of LINE1 retrotransposon transcripts and male infertility.

Date: 2011
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DOI: 10.1038/nature10672

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