Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

Filippo M. Cernilogar, Maria Cristina Onorati, Greg O. Kothe, A. Maxwell Burroughs, Krishna Mohan Parsi, Achim Breiling, Federica Lo Sardo, Alka Saxena, Keita Miyoshi, Haruhiko Siomi, Mikiko C. Siomi, Piero Carninci, David S. Gilmour, Davide F. V. Corona and Valerio Orlando ()
Additional contact information
Filippo M. Cernilogar: Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64
Maria Cristina Onorati: Dulbecco Telethon Institute at Università degli Studi di Palermo, Sezione Biologia Cellulare, Viale delle Scienze, Edificio 16
Greg O. Kothe: Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park
A. Maxwell Burroughs: RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama
Krishna Mohan Parsi: Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64
Achim Breiling: DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 580
Federica Lo Sardo: Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64
Alka Saxena: RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama
Keita Miyoshi: Keio University School of Medicine
Haruhiko Siomi: Keio University School of Medicine
Mikiko C. Siomi: Keio University School of Medicine
Piero Carninci: RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama
David S. Gilmour: Center for Eukaryotic Gene Regulation, The Pennsylvania State University, University Park
Davide F. V. Corona: Dulbecco Telethon Institute at Università degli Studi di Palermo, Sezione Biologia Cellulare, Viale delle Scienze, Edificio 16
Valerio Orlando: Dulbecco Telethon Institute, Epigenetics and Genome Reprogramming, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64

Nature, 2011, vol. 480, issue 7377, 391-395

Abstract: Nuclear role for RNAi RNA interference (RNAi) is generally associated with post-transcriptional gene silencing, but there is growing evidence that small RNAs and RNAi components also have a role in transcriptional gene silencing in the nucleus. This study shows that, in Drosophila, the RNAi components Dicer-2 (Dcr2) and Argonaute-2 (AGO2) are present in the nucleus, associating with transcriptionally active gene loci and interacting with RNA polymerase II. Dcr2 and AGO2 are associated with sense and antisense transcripts and seem to have a role in regulating transcription, particularly during heatshock.

Date: 2011
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DOI: 10.1038/nature10492

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