Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

Fang Sun, Kevin K. Park, Stephane Belin, Dongqing Wang, Tao Lu, Gang Chen, Kang Zhang, Cecil Yeung, Guoping Feng, Bruce A. Yankner and Zhigang He ()
Additional contact information
Fang Sun: F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School
Kevin K. Park: Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami
Stephane Belin: F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School
Dongqing Wang: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Tao Lu: Harvard Medical School
Gang Chen: F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School
Kang Zhang: Shiley Eye Center, University of California at San Diego
Cecil Yeung: F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School
Guoping Feng: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Bruce A. Yankner: Harvard Medical School
Zhigang He: F.M. Kirby Neurobiology Center, Children’s Hospital, Harvard Medical School

Nature, 2011, vol. 480, issue 7377, 372-375

Abstract: Nerve regeneration at a distance Long-range extensive repair following nerve damage has been demonstrated in the peripheral nervous system, but such robust regeneration is rare in the central nervous system. Previous studies have observed some repair following molecular manipulations of the regeneration signalling pathways, but these gains often tapered off after two weeks. Zhigang He and colleagues identify a modification to two signalling pathways that promotes enhanced axonal regeneration following a nerve crush injury. These manipulated pathways act in synergy to promote the expression of growth-related genes that maintain high enough levels to sustain long-range regenerative growth.

Date: 2011
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DOI: 10.1038/nature10594

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