Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB

Vincent J. Lynch (), Gemma May and Günter P. Wagner
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Vincent J. Lynch: Yale University
Gemma May: Yale University
Günter P. Wagner: Yale University

Nature, 2011, vol. 480, issue 7377, 383-386

Abstract: Evolution of gene regulation Changes in cis-regulatory regions of the genome play an important part in the evolution of gene regulation. Lynch et al. explore the influence of amino acid substitutions in transcription factors on gene regulation. They show how, over evolutionary time, amino acid substitutions in the transcription factor CEBPB in the stem-lineage of placental mammals reorganize the location of key phosphorylation sites, thereby changing the way it responds to cAMP/PKA signalling.

Date: 2011
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DOI: 10.1038/nature10595

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