Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

Sonja Kriks, Jae-Won Shim, Jinghua Piao, Yosif M. Ganat, Dustin R. Wakeman, Zhong Xie, Luis Carrillo-Reid, Gordon Auyeung, Chris Antonacci, Amanda Buch, Lichuan Yang, M. Flint Beal, D. James Surmeier, Jeffrey H. Kordower, Viviane Tabar and Lorenz Studer ()
Additional contact information
Sonja Kriks: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Jae-Won Shim: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Jinghua Piao: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Yosif M. Ganat: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Dustin R. Wakeman: Rush University Medical Center
Zhong Xie: Feinberg School of Medicine, Northwestern University
Luis Carrillo-Reid: Feinberg School of Medicine, Northwestern University
Gordon Auyeung: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Chris Antonacci: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Amanda Buch: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Lichuan Yang: Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, New York 10021, USA
M. Flint Beal: Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, New York 10021, USA
D. James Surmeier: Feinberg School of Medicine, Northwestern University
Jeffrey H. Kordower: Rush University Medical Center
Viviane Tabar: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Lorenz Studer: Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA

Nature, 2011, vol. 480, issue 7378, 547-551

Abstract: A new strategy for derivation of human midbrain dopamine neurons from pluripotent cells was developed; transplantation of the neurons in mice, rats and parkinsonian monkeys show they are a promising source of cells for applications in regenerative medicine.

Date: 2011
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DOI: 10.1038/nature10648

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