Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease

Philipp Koch, Peter Breuer, Michael Peitz, Johannes Jungverdorben, Jaideep Kesavan, Daniel Poppe, Jonas Doerr, Julia Ladewig, Jerome Mertens, Thomas Tüting, Per Hoffmann, Thomas Klockgether, Bernd O. Evert, Ullrich Wüllner and Oliver Brüstle ()
Additional contact information
Philipp Koch: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Peter Breuer: University of Bonn Medical Center, 53105 Bonn, Germany
Michael Peitz: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Johannes Jungverdorben: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Jaideep Kesavan: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Daniel Poppe: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Jonas Doerr: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Julia Ladewig: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Jerome Mertens: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation
Thomas Tüting: University of Bonn Medical Center, 53127 Bonn, Germany
Per Hoffmann: Life and Brain Center, University of Bonn, 53127 Bonn, Germany
Thomas Klockgether: University of Bonn Medical Center, 53105 Bonn, Germany
Bernd O. Evert: University of Bonn Medical Center, 53105 Bonn, Germany
Ullrich Wüllner: University of Bonn Medical Center, 53105 Bonn, Germany
Oliver Brüstle: Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation

Nature, 2011, vol. 480, issue 7378, 543-546

Abstract: Human neurons derived from induced pluripotent stem cells permit the study of aberrant protein processing and aggregation in Machado–Joseph disease.

Date: 2011
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DOI: 10.1038/nature10671

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