Rethinking amide bond synthesis

Vijaya R. Pattabiraman and Jeffrey W. Bode ()
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Vijaya R. Pattabiraman: Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich, Switzerland
Jeffrey W. Bode: Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich, Switzerland

Nature, 2011, vol. 480, issue 7378, 471-479

Abstract: Recent advances in amide-bond-forming reactions are reviewed and summarized, highlighting the successful implementation of new synthetic methodologies and the limitations that need to be overcome to efficiently make the next generation of conventional small-molecule pharmaceuticals, therapeutic peptides, and natural and non-natural proteins.

Date: 2011
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DOI: 10.1038/nature10702

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