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Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

Peng Yuan, Manuel D. Leonetti, Yichun Hsiung and Roderick MacKinnon ()
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Peng Yuan: Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA
Manuel D. Leonetti: Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA
Yichun Hsiung: Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA
Roderick MacKinnon: Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA

Nature, 2012, vol. 481, issue 7379, 94-97

Abstract: The crystal structure of the calcium-bound gating ring of a calcium- and voltage-activated potassium channel shows in detail how the effect of calcium binding on the gating ring produces the conformational change from closed to open.

Date: 2012
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DOI: 10.1038/nature10670

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