FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

Shanshan Duan, Lukas Cermak, Julia K. Pagan, Mario Rossi, Cinzia Martinengo, Paola Francia di Celle, Bjoern Chapuy, Margaret Shipp, Roberto Chiarle () and Michele Pagano ()
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Shanshan Duan: NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
Lukas Cermak: NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
Julia K. Pagan: NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
Mario Rossi: NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
Cinzia Martinengo: CERMS, University of Torino, 10126 Torino, Italy
Paola Francia di Celle: San Giovanni Battista Hospital, Via Santena 7, 10126 Torino, Italy
Bjoern Chapuy: Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
Margaret Shipp: Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
Roberto Chiarle: CERMS, University of Torino, 10126 Torino, Italy
Michele Pagano: NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA

Nature, 2012, vol. 481, issue 7379, 90-93

Abstract: FBXO11 is identified as the F-box protein that normally targets BCL6 for degradation, and FBXO11 deletions or mutations that prevent this function and thus stabilize BCL6 are found in B-cell lymphomas.

Date: 2012
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DOI: 10.1038/nature10688

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