Interactions between cancer stem cells and their niche govern metastatic colonization

Ilaria Malanchi, Albert Santamaria-Martínez, Evelyn Susanto, Hong Peng, Hans-Anton Lehr, Jean-Francois Delaloye and Joerg Huelsken ()
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Ilaria Malanchi: Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’
Albert Santamaria-Martínez: Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’
Evelyn Susanto: Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’
Hong Peng: Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’
Hans-Anton Lehr: University Institute of Pathology, CHUV, University of Lausanne
Jean-Francois Delaloye: Centre Hospitalier Universitaire Vaudois
Joerg Huelsken: Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research and National Center of Competence in Research ‘Molecular Oncology’

Nature, 2012, vol. 481, issue 7379, 85-89

Abstract: For the initiation of metastasis, there must be a small population of cancer stem cells at the secondary site and, to maintain this population and allow proliferation, infiltrating cancer cells must induce the expression of stromal periostin.

Date: 2012
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DOI: 10.1038/nature10694

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