Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour

Vincent Pascoli, Marc Turiault and Christian Lüscher ()
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Vincent Pascoli: Medical Faculty, University of Geneva
Marc Turiault: Medical Faculty, University of Geneva
Christian Lüscher: Medical Faculty, University of Geneva

Nature, 2012, vol. 481, issue 7379, 71-75

Abstract: In mice, cocaine is found to potentiate excitatory transmission in medium-sized spiny neurons expressing the type-1 dopamine receptor; depotentiation reversed cocaine-induced locomotor sensitization, raising the possibility of novel treatments for addiction.

Date: 2012
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DOI: 10.1038/nature10709

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