Basic amino-acid side chains regulate transmembrane integrin signalling

Chungho Kim, Thomas Schmidt, Eun-Gyung Cho, Feng Ye, Tobias S. Ulmer () and Mark H. Ginsberg ()
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Chungho Kim: University of California, San Diego, La Jolla, California 92093, USA
Thomas Schmidt: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
Eun-Gyung Cho: Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA
Feng Ye: University of California, San Diego, La Jolla, California 92093, USA
Tobias S. Ulmer: Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
Mark H. Ginsberg: University of California, San Diego, La Jolla, California 92093, USA

Nature, 2012, vol. 481, issue 7380, 209-213

Abstract: Loss of a snorkelling residue in integrin β TMDs changes membrane embedding and affects transmembrane signalling, showing that snorkelling can have an important role in signal transduction

Date: 2012
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DOI: 10.1038/nature10697

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