Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

Jörg H. Fritz, Olga Lucia Rojas, Nathalie Simard, Douglas D. McCarthy, Siegfried Hapfelmeier, Stephen Rubino, Susan J. Robertson, Mani Larijani, Jean Gosselin, Ivaylo I. Ivanov, Alberto Martin, Rafael Casellas, Dana J. Philpott, Stephen E. Girardin, Kathy D. McCoy, Andrew J. Macpherson, Christopher J. Paige and Jennifer L. Gommerman ()
Additional contact information
Jörg H. Fritz: University of Toronto
Olga Lucia Rojas: University of Toronto
Nathalie Simard: University of Toronto
Douglas D. McCarthy: University of Toronto
Siegfried Hapfelmeier: University of Bern
Stephen Rubino: University of Toronto
Susan J. Robertson: University of Toronto
Mani Larijani: University of Toronto
Jean Gosselin: University of Laval
Ivaylo I. Ivanov: Columbia University Medical Center, College of Physicians and Surgeons
Alberto Martin: University of Toronto
Rafael Casellas: Genomics and Immunity, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
Dana J. Philpott: University of Toronto
Stephen E. Girardin: University of Toronto
Kathy D. McCoy: University of Bern
Andrew J. Macpherson: University of Bern
Christopher J. Paige: University of Toronto
Jennifer L. Gommerman: University of Toronto

Nature, 2012, vol. 481, issue 7380, 199-203

Abstract: IgA secreting plasma cells in the lamina propria are shown to be an important source of iNOS and TNF required to maintain the homeostatic balance between intestinal microbes and the immune system.

Date: 2012
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DOI: 10.1038/nature10698

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