Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Hsien-Sung Huang, John A. Allen, Angela M. Mabb, Ian F. King, Jayalakshmi Miriyala, Bonnie Taylor-Blake, Noah Sciaky, J. Walter Dutton, Hyeong-Min Lee, Xin Chen, Jian Jin, Arlene S. Bridges, Mark J. Zylka (), Bryan L. Roth () and Benjamin D. Philpot ()
Additional contact information
Hsien-Sung Huang: University of North Carolina School of Medicine
John A. Allen: University of North Carolina School of Medicine
Angela M. Mabb: University of North Carolina School of Medicine
Ian F. King: University of North Carolina School of Medicine
Jayalakshmi Miriyala: University of North Carolina School of Medicine
Bonnie Taylor-Blake: University of North Carolina School of Medicine
Noah Sciaky: University of North Carolina School of Medicine
J. Walter Dutton: University of North Carolina School of Medicine
Hyeong-Min Lee: University of North Carolina School of Medicine
Xin Chen: Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina Eshelman School of Pharmacy
Jian Jin: Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina Eshelman School of Pharmacy
Arlene S. Bridges: University of North Carolina School of Medicine
Mark J. Zylka: University of North Carolina School of Medicine
Bryan L. Roth: University of North Carolina School of Medicine
Benjamin D. Philpot: University of North Carolina School of Medicine

Nature, 2012, vol. 481, issue 7380, 185-189

Abstract: Cancer drugs that can potentially treat Angelman syndrome are identified.

Date: 2012
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DOI: 10.1038/nature10726

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