Reductive carboxylation supports growth in tumour cells with defective mitochondria

Andrew R. Mullen, William W. Wheaton, Eunsook S. Jin, Pei-Hsuan Chen, Lucas B. Sullivan, Tzuling Cheng, Youfeng Yang, W. Marston Linehan, Navdeep S. Chandel () and Ralph J. DeBerardinis ()
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Andrew R. Mullen: University of Texas – Southwestern Medical Center at Dallas
William W. Wheaton: Northwestern University
Eunsook S. Jin: University of Texas – Southwestern Medical Center at Dallas
Pei-Hsuan Chen: University of Texas – Southwestern Medical Center at Dallas
Lucas B. Sullivan: Northwestern University
Tzuling Cheng: University of Texas – Southwestern Medical Center at Dallas
Youfeng Yang: Urologic Oncology Branch, National Cancer Institute
W. Marston Linehan: Urologic Oncology Branch, National Cancer Institute
Navdeep S. Chandel: Northwestern University
Ralph J. DeBerardinis: University of Texas – Southwestern Medical Center at Dallas

Nature, 2012, vol. 481, issue 7381, 385-388

Abstract: Tumour cells with defective mitochondria are found to use glutamine-dependent reductive carboxylation, rather than oxidative metabolism, as the major pathway of citrate and lipid formation.

Date: 2012
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DOI: 10.1038/nature10642

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