Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

Stefanie Jäger, Dong Young Kim, Judd F. Hultquist, Keisuke Shindo, Rebecca S. LaRue, Eunju Kwon, Ming Li, Brett D. Anderson, Linda Yen, David Stanley, Cathal Mahon, Joshua Kane, Kathy Franks-Skiba, Peter Cimermancic, Alma Burlingame, Andrej Sali, Charles S. Craik, Reuben S. Harris (), John D. Gross () and Nevan J. Krogan ()
Additional contact information
Stefanie Jäger: University of California-San Francisco
Dong Young Kim: University of California
Judd F. Hultquist: Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
Keisuke Shindo: Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
Rebecca S. LaRue: Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
Eunju Kwon: University of California
Ming Li: Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
Brett D. Anderson: Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
Linda Yen: University of California
David Stanley: University of California
Cathal Mahon: University of California-San Francisco
Joshua Kane: University of California-San Francisco
Kathy Franks-Skiba: University of California-San Francisco
Peter Cimermancic: California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
Alma Burlingame: California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
Andrej Sali: California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
Charles S. Craik: California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
Reuben S. Harris: Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota
John D. Gross: California Institute for Quantitative Biosciences, QB3, San Francisco, California, California 94158, USA
Nevan J. Krogan: University of California-San Francisco

Nature, 2012, vol. 481, issue 7381, 371-375

Abstract: The transcription cofactor CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3; it acts by interacting with the HIV protein Vif, so disrupting the Vif–CBF-β interaction could provide a new therapeutic target against HIV-1 infection.

Date: 2012
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DOI: 10.1038/nature10693

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