Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Caryn S. Ross-Innes, Rory Stark, Andrew E. Teschendorff, Kelly A. Holmes, H. Raza Ali, Mark J. Dunning, Gordon D. Brown, Ondrej Gojis, Ian O. Ellis, Andrew R. Green, Simak Ali, Suet-Feung Chin, Carlo Palmieri, Carlos Caldas () and Jason S. Carroll ()
Additional contact information
Caryn S. Ross-Innes: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Rory Stark: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Andrew E. Teschendorff: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK
Kelly A. Holmes: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
H. Raza Ali: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Mark J. Dunning: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Gordon D. Brown: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Ondrej Gojis: Imperial College London, Hammersmith Campus, London W12 0NN, UK
Ian O. Ellis: Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
Andrew R. Green: Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK
Simak Ali: Imperial College London, Hammersmith Campus, London W12 0NN, UK
Suet-Feung Chin: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Carlo Palmieri: Imperial College London, Hammersmith Campus, London W12 0NN, UK
Carlos Caldas: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Jason S. Carroll: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK

Nature, 2012, vol. 481, issue 7381, 389-393

Abstract: Genome-wide mapping of oestrogen receptor-α binding sites in primary breast cancer tissues shows that oestrogen receptor binding is dynamically regulated and that the expression of genes near differentially bound regulatory regions is associated with clinical outcome.

Date: 2012
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DOI: 10.1038/nature10730

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