Clonal evolution in cancer

Mel Greaves () and Carlo C. Maley
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Mel Greaves: The Institute of Cancer Research
Carlo C. Maley: Center for Evolution and Cancer, Helen Diller Family Comprehensive Cancer Center, University of California

Nature, 2012, vol. 481, issue 7381, 306-313

Abstract: Abstract Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

Date: 2012
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DOI: 10.1038/nature10762

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