The contribution of bone to whole-organism physiology

Gérard Karsenty () and Mathieu Ferron
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Gérard Karsenty: College of Physicians and Surgeons, Columbia University
Mathieu Ferron: College of Physicians and Surgeons, Columbia University

Nature, 2012, vol. 481, issue 7381, 314-320

Abstract: Abstract The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.

Date: 2012
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DOI: 10.1038/nature10763

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