Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Li Ding, Timothy J. Ley (), David E. Larson, Christopher A. Miller, Daniel C. Koboldt, John S. Welch, Julie K. Ritchey, Margaret A. Young, Tamara Lamprecht, Michael D. McLellan, Joshua F. McMichael, John W. Wallis, Charles Lu, Dong Shen, Christopher C. Harris, David J. Dooling, Robert S. Fulton, Lucinda L. Fulton, Ken Chen, Heather Schmidt, Joelle Kalicki-Veizer, Vincent J. Magrini, Lisa Cook, Sean D. McGrath, Tammi L. Vickery, Michael C. Wendl, Sharon Heath, Mark A. Watson, Daniel C. Link, Michael H. Tomasson, William D. Shannon, Jacqueline E. Payton, Shashikant Kulkarni, Peter Westervelt, Matthew J. Walter, Timothy A. Graubert, Elaine R. Mardis, Richard K. Wilson and John F. DiPersio
Additional contact information
Li Ding: The Genome Institute, Washington University
Timothy J. Ley: The Genome Institute, Washington University
David E. Larson: The Genome Institute, Washington University
Christopher A. Miller: The Genome Institute, Washington University
Daniel C. Koboldt: The Genome Institute, Washington University
John S. Welch: Washington University
Julie K. Ritchey: Washington University
Margaret A. Young: Washington University
Tamara Lamprecht: Washington University
Michael D. McLellan: The Genome Institute, Washington University
Joshua F. McMichael: The Genome Institute, Washington University
John W. Wallis: The Genome Institute, Washington University
Charles Lu: The Genome Institute, Washington University
Dong Shen: The Genome Institute, Washington University
Christopher C. Harris: The Genome Institute, Washington University
David J. Dooling: The Genome Institute, Washington University
Robert S. Fulton: The Genome Institute, Washington University
Lucinda L. Fulton: The Genome Institute, Washington University
Ken Chen: The Genome Institute, Washington University
Heather Schmidt: The Genome Institute, Washington University
Joelle Kalicki-Veizer: The Genome Institute, Washington University
Vincent J. Magrini: The Genome Institute, Washington University
Lisa Cook: The Genome Institute, Washington University
Sean D. McGrath: The Genome Institute, Washington University
Tammi L. Vickery: The Genome Institute, Washington University
Michael C. Wendl: The Genome Institute, Washington University
Sharon Heath: Washington University
Mark A. Watson: Washington University
Daniel C. Link: Washington University
Michael H. Tomasson: Washington University
William D. Shannon: Washington University
Jacqueline E. Payton: Washington University
Shashikant Kulkarni: Washington University
Peter Westervelt: Washington University
Matthew J. Walter: Washington University
Timothy A. Graubert: Washington University
Elaine R. Mardis: The Genome Institute, Washington University
Richard K. Wilson: The Genome Institute, Washington University
John F. DiPersio: Washington University

Nature, 2012, vol. 481, issue 7382, 506-510

Abstract: The sequencing of AML genomes of eight patients before and after relapse reveals two major patterns of clonal evolution, with chemotherapy appearing to have a role in both patterns.

Date: 2012
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DOI: 10.1038/nature10738

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