Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia

Duan-Sun Zhang, Valeria Piazza, Benjamin J. Perrin, Agnieszka K. Rzadzinska, J. Collin Poczatek, Mei Wang, Haydn M. Prosser, James M. Ervasti, David P. Corey () and Claude P. Lechene ()
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Duan-Sun Zhang: Harvard Medical School and Howard Hughes Medical Institute
Valeria Piazza: Harvard Medical School and Howard Hughes Medical Institute
Benjamin J. Perrin: Molecular Biology and Biophysics, University of Minnesota
Agnieszka K. Rzadzinska: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
J. Collin Poczatek: National Resource for Imaging Mass Spectrometry, Brigham and Women’s Hospital and Harvard Medical School
Mei Wang: National Resource for Imaging Mass Spectrometry, Brigham and Women’s Hospital and Harvard Medical School
Haydn M. Prosser: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
James M. Ervasti: Molecular Biology and Biophysics, University of Minnesota
David P. Corey: Harvard Medical School and Howard Hughes Medical Institute
Claude P. Lechene: National Resource for Imaging Mass Spectrometry, Brigham and Women’s Hospital and Harvard Medical School

Nature, 2012, vol. 481, issue 7382, 520-524

Abstract: Multi-isotope imaging mass spectrometry is used to quantify protein turnover in animal stereocilia, showing that rapid turnover occurs only in stereocilia tips.

Date: 2012
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DOI: 10.1038/nature10745

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