Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

Congcong He, Michael C. Bassik, Viviana Moresi, Kai Sun, Yongjie Wei, Zhongju Zou, Zhenyi An, Joy Loh, Jill Fisher, Qihua Sun, Stanley Korsmeyer, Milton Packer, Herman I. May, Joseph A. Hill, Herbert W. Virgin, Christopher Gilpin, Guanghua Xiao, Rhonda Bassel-Duby, Philipp E. Scherer and Beth Levine ()
Additional contact information
Congcong He: Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Michael C. Bassik: Dana-Farber Cancer Institute, Massachusetts 02115, USA
Viviana Moresi: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Kai Sun: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Yongjie Wei: Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Zhongju Zou: Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Zhenyi An: Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Joy Loh: Washington University School of Medicine
Jill Fisher: Dana-Farber Cancer Institute, Massachusetts 02115, USA
Qihua Sun: Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Stanley Korsmeyer: Dana-Farber Cancer Institute, Massachusetts 02115, USA
Milton Packer: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Herman I. May: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Joseph A. Hill: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Herbert W. Virgin: Washington University School of Medicine
Christopher Gilpin: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Guanghua Xiao: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Rhonda Bassel-Duby: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Philipp E. Scherer: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Beth Levine: Center for Autophagy Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA

Nature, 2012, vol. 481, issue 7382, 511-515

Abstract: Acute exercise is shown to induce autophagy in skeletal muscle of fed mice, indicating a possible mechanism for the beneficial metabolic effects of exercise.

Date: 2012
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DOI: 10.1038/nature10758

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