Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

Philipp Engel, Arnaud Goepfert, Frédéric V. Stanger, Alexander Harms, Alexander Schmidt, Tilman Schirmer () and Christoph Dehio ()
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Philipp Engel: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Arnaud Goepfert: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Frédéric V. Stanger: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Alexander Harms: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Alexander Schmidt: Proteomics Core Facility, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Tilman Schirmer: Core Program Structural Biology and Biophysics, Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Christoph Dehio: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland

Nature, 2012, vol. 482, issue 7383, 107-110

Abstract: FIC-domain-mediated adenylylation is controlled by inter- or intramolecular disturbance of the ATP binding site by an α-helix; such inhibition seems to be universal and conserved through evolution.

Date: 2012
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DOI: 10.1038/nature10729

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