Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression

Siaw-Wei Ng, Daniel Bakowski, Charmaine Nelson, Ravi Mehta, Robert Almeyda, Grant Bates and Anant B. Parekh ()
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Siaw-Wei Ng: Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Daniel Bakowski: Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Charmaine Nelson: Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Ravi Mehta: Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Robert Almeyda: John Radcliffe Hospital, Oxford OX3 9DH, UK
Grant Bates: John Radcliffe Hospital, Oxford OX3 9DH, UK
Anant B. Parekh: Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK

Nature, 2012, vol. 482, issue 7383, 111-115

Abstract: Rather than turning off the biological response, desensitization of the cysteinyl leukotriene type I receptor sustains long-term signalling in the immune system.

Date: 2012
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DOI: 10.1038/nature10731

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