Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

Natasha M. DeVore and Emily E. Scott ()
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Natasha M. DeVore: 1251 Wescoe Hall Drive, University of Kansas
Emily E. Scott: 1251 Wescoe Hall Drive, University of Kansas

Nature, 2012, vol. 482, issue 7383, 116-119

Abstract: The structures of CYP17A1 with steroid inhibitors abiraterone or TOK-001 provide a better understanding of the enzyme’s catalytic capabilities and inhibition, and hence assist in understanding steroidogenic diseases and designing drugs to improve the treatment of prostate and other steroid-responsive cancers.

Date: 2012
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DOI: 10.1038/nature10743

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