Gated regulation of CRAC channel ion selectivity by STIM1

Beth A. McNally, Agila Somasundaram, Megumi Yamashita and Murali Prakriya ()
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Beth A. McNally: Northwestern University School of Medicine, 303 E Chicago Avenue, Ward 8-296, Chicago, Illinois 60611, USA
Agila Somasundaram: Northwestern University School of Medicine, 303 E Chicago Avenue, Ward 8-296, Chicago, Illinois 60611, USA
Megumi Yamashita: Northwestern University School of Medicine, 303 E Chicago Avenue, Ward 8-296, Chicago, Illinois 60611, USA
Murali Prakriya: Northwestern University School of Medicine, 303 E Chicago Avenue, Ward 8-296, Chicago, Illinois 60611, USA

Nature, 2012, vol. 482, issue 7384, 241-245

Abstract: STIM1-mediated gating of CRAC channels occurs through a mechanism in which ion selectivity and gating are closely coupled, and the residue V102 is identified as a candidate for the channel gate.

Date: 2012
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DOI: 10.1038/nature10752

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