High-throughput decoding of antitrypanosomal drug efficacy and resistance

Sam Alsford, Sabine Eckert, Nicola Baker, Lucy Glover, Alejandro Sanchez-Flores, Ka Fai Leung, Daniel J. Turner, Mark C. Field, Matthew Berriman and David Horn ()
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Sam Alsford: London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Sabine Eckert: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
Nicola Baker: London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Lucy Glover: London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
Alejandro Sanchez-Flores: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
Ka Fai Leung: University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
Daniel J. Turner: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
Mark C. Field: University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
Matthew Berriman: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
David Horn: London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK

Nature, 2012, vol. 482, issue 7384, 232-236

Abstract: Five current human African trypanosomiasis drugs are used for genome-scale RNA interference target sequencing screens in Trypanosoma brucei, and reveal the transporters, organelles, enzymes and metabolic pathways that function to facilitate antitrypanosomal drug action.

Date: 2012
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DOI: 10.1038/nature10771

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