Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Warren A. Whyte, Steve Bilodeau, David A. Orlando, Heather A. Hoke, Garrett M. Frampton, Charles T. Foster, Shaun M. Cowley and Richard A. Young ()
Additional contact information
Warren A. Whyte: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Steve Bilodeau: Whitehead Institute for Biomedical Research, 9 Cambridge Center
David A. Orlando: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Heather A. Hoke: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Garrett M. Frampton: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Charles T. Foster: Adolf-Butenandt Institut, Ludwig-Maximilians-Universität München, 80336 Munich, Germany
Shaun M. Cowley: University of Leicester, Leicester LE1 9HN, UK
Richard A. Young: Whitehead Institute for Biomedical Research, 9 Cambridge Center

Nature, 2012, vol. 482, issue 7384, 221-225

Abstract: In embryonic stem cells, the histone demethylase LSD1 occupies the enhancers of active genes and, together with the NuRD complex, decommissions the enhancers during differentiation.

Date: 2012
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DOI: 10.1038/nature10805

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