The Drosophila melanogaster Genetic Reference Panel

Trudy F. C. Mackay (), Stephen Richards, Eric A. Stone, Antonio Barbadilla, Julien F. Ayroles, Dianhui Zhu, Sònia Casillas, Yi Han, Michael M. Magwire, Julie M. Cridland, Mark F. Richardson, Robert R. H. Anholt, Maite Barrón, Crystal Bess, Kerstin Petra Blankenburg, Mary Anna Carbone, David Castellano, Lesley Chaboub, Laura Duncan, Zeke Harris, Mehwish Javaid, Joy Christina Jayaseelan, Shalini N. Jhangiani, Katherine W. Jordan, Fremiet Lara, Faye Lawrence, Sandra L. Lee, Pablo Librado, Raquel S. Linheiro, Richard F. Lyman, Aaron J. Mackey, Mala Munidasa, Donna Marie Muzny, Lynne Nazareth, Irene Newsham, Lora Perales, Ling-Ling Pu, Carson Qu, Miquel Ràmia, Jeffrey G. Reid, Stephanie M. Rollmann, Julio Rozas, Nehad Saada, Lavanya Turlapati, Kim C. Worley, Yuan-Qing Wu, Akihiko Yamamoto, Yiming Zhu, Casey M. Bergman, Kevin R. Thornton, David Mittelman and Richard A. Gibbs
Additional contact information
Trudy F. C. Mackay: North Carolina State University
Stephen Richards: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Eric A. Stone: North Carolina State University
Antonio Barbadilla: Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Julien F. Ayroles: North Carolina State University
Dianhui Zhu: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Sònia Casillas: Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Yi Han: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Michael M. Magwire: North Carolina State University
Julie M. Cridland: University of California - Irvine
Mark F. Richardson: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Robert R. H. Anholt: North Carolina State University
Maite Barrón: Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Crystal Bess: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Kerstin Petra Blankenburg: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Mary Anna Carbone: North Carolina State University
David Castellano: Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Lesley Chaboub: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Laura Duncan: North Carolina State University
Zeke Harris: North Carolina State University
Mehwish Javaid: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Joy Christina Jayaseelan: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Shalini N. Jhangiani: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Katherine W. Jordan: North Carolina State University
Fremiet Lara: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Faye Lawrence: North Carolina State University
Sandra L. Lee: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Pablo Librado: Molecular Evolutionary Genetics Group, Faculty of Biology, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Raquel S. Linheiro: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Richard F. Lyman: North Carolina State University
Aaron J. Mackey: Center for Public Health Genomics, University of Virginia, PO Box 800717, Charlottesville, Virginia 22908, USA
Mala Munidasa: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Donna Marie Muzny: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Lynne Nazareth: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Irene Newsham: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Lora Perales: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Ling-Ling Pu: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Carson Qu: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Miquel Ràmia: Genomics, Bioinformatics and Evolution Group, Campus Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Jeffrey G. Reid: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Stephanie M. Rollmann: North Carolina State University
Julio Rozas: Molecular Evolutionary Genetics Group, Faculty of Biology, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
Nehad Saada: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Lavanya Turlapati: North Carolina State University
Kim C. Worley: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Yuan-Qing Wu: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Akihiko Yamamoto: North Carolina State University
Yiming Zhu: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA
Casey M. Bergman: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Kevin R. Thornton: University of California - Irvine
David Mittelman: Virginia Tech
Richard A. Gibbs: Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 USA

Nature, 2012, vol. 482, issue 7384, 173-178

Abstract: Abstract A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of Drosophila genetics.

Date: 2012
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature10811 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:482:y:2012:i:7384:d:10.1038_nature10811

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10811

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().